Letrozole: An Overview of Its Uses and Benefits

Letrozole is a medication primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It belongs to a class of drugs known as aromatase inhibitors, which work by lowering estrogen levels in the body. This reduction helps slow or stop the growth of certain types of breast tumors that require estrogen to grow.

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How Does Letrozole Work?

Letrozole interferes with the aromatase enzyme, which is responsible for converting androgens into estrogen. Here is how it functions:

1. Reducing Estrogen Production: By inhibiting the aromatase enzyme, letrozole effectively lowers the overall production of estrogen in the body.
2. Slowing Cancer Growth: Many breast cancer cells thrive on estrogen; thus, reducing its levels can slow down the growth of these cells.
3. Preventing Recurrence: Letrozole is also used as adjuvant therapy to decrease the risk of breast cancer recurrence after initial treatment.

Uses of Letrozole

Aside from its primary application in breast cancer treatment, letrozole has other uses, including:

1. Ovulation Induction: Letrozole is sometimes prescribed off-label to help women with polycystic ovary syndrome (PCOS) who are trying to conceive.
2. Endometriosis Treatment: It may be used to manage symptoms of endometriosis by reducing estrogen levels.

Side Effects

Like any medication, letrozole can cause side effects. Common side effects include:

1. Hot flashes
2. Joint pain or stiffness
3. Fatigue
4. Nausea
5. Increased cholesterol levels

Conclusion

Letrozole plays a significant role in the management of hormone receptor-positive breast cancer and has additional applications in fertility treatments and other hormonal conditions. However, as with any medication, it is essential to discuss its use with a healthcare professional to ensure it is appropriate for your situation.